Clark (Tom Welling) must solve the riddle of the mysterious Nicodemus flower and Lex's (Michael Rosenbaum) shady involvement after it infects the residents of Smallville removing their inhibitions - Jonathan (John Schneider) becomes a couch potato, Lana (Kristin Kreuk) puts the moves on Clark as the town Lolita and Pete (Sam Jones III) tries to kill Lex - then puts them into a deadly coma.
Allison Mack, Eric Johnson and Annette O'Toole also star. James Marshall directed the episode; written by Greg Walker with teleplay by Michael Green.

Jonathan comes to the rescue of a LuthorCorp employee who is acting insanely and crashes his car. The man is carrying a flower which sprays Jonathan in the face. Jonathan then starts acting wildly uninhibited, tries to shoot his bank loan officer, and lapses into a coma. When Chloe and Lana go out to investigate the crash site, The next morning lana come to school looking sexy and wild. she then breaks up with Whitney for refusing to have "Fun" with her, and heads for Clark. While with Clack she gives him words of inspiration for troubled times, and then seduces him to come with her to the pool. Lana heads for the diving board, and begins to take of her boots. While Clark is saying that something is wrong with her she keeps stripping and takes her mini skirt and tank top. Then she dive into the pool. Luthor's pet meteor scientist, Hamilton, is experimenting with meteor-rock radiation and its effects on the Nicodemus flower, which caused a plague of fever, madness, and eventual death in the area 100 years ago, and the LuthorCorp employee stole it.

Clark and his friends make the connection, but Pete gets infected as well. Blaming Lex for the loss of his family's creamed corn company at the hands of his father, he tries to shoot Lex just as he finds a cure from an old diary. Clark comes to the rescue, and fortunately no one remembers anything they did while they were delusional. Lex lies to Clark about his involvement with Hamilton and tucks Hamilton safely away where no one can find him while he does further research.

Lana: You think too much, Clark.
Clark: Right now I'm thinking this doesn't seem like you.
Lana: Or maybe (undresses) I'm more me than ever.

Lex: Pete, I'm going to reach in there and get that book. If you want to shoot me...go ahead.
Pete: No problem.

Lana: I know you want me, Clark. Stop holding back. Come on, you're not made of steel...or are you?

Lana: If life doesn't make you crazy, then why bother living it? I know that's how I want it. The question is, do you want what I want?

Lana: You like it?
Clark: Uh, I think the operative word is "gulp".

Lex: "On God's green earth, this flower was the thief in the temple, the silent temptress that, with a single sneeze brought out the basest instincts in men and drove them to violence."

Dr. Hamilton: A situation's come up in my lab.
Lex: Don't you mean your barn?

Chloe: It's a first hand account of Smallville's first mystery. In 1871 the whole settlement went postal before they even had a post office.
Pete: Nice to know Smallville was still whack even before the meteors got here.

Chloe: Principal Kwan thinks that I need to get more in touch with the pulse of the student body so I've decided to do a poll. Now, if you would both please do your statistical duty...
Pete: I'd go over and make out with that girl right now...
Chloe: You know, every answer I've gotten so far has been either sex or violence-related.
Pete: That's human nature, Chloe.

Pete: Wow. Drinking beer, mouthing off, and counter macking with your mom. Congratulations, Clark, your dad has regressed to being a teenager.

Clark: (after catching his parents "counter macking") I did not need to see that!

Dr. Hamilton: Remember, Lex, you're the one opening Pandora's Box.
Pete: I'm just the key, Dr. Hamilton

The Nicodemus is a flower that lived over a hundred years ago, and killed a whole settlement in the area. It produces a yellow dust which causes the recipient to behave with unrepressed feelings for a couple of hours, then faint and go into a coma, and finally die. Dr. Steven Hamilton, who has been hired by Lex Luthor to discover the effects of meteor, was able to revive this flower with the power of the rocks. The first victim is James Beals, an employee of LuthorCorp who stole the flower, obviously got infected and with unrepressed feelings demands to speak to Lionel Luthor to tell him his exact feelings.

On the road, James gets involved in a crash with Jonathan Kent, who saves him, but not before getting affected by the flower as well. Jonathan strange behavior can be seen by passionately kissing Martha all day, lashing out unfairly at Lex and driving into town with a shotgun. Clark Kent manages to stop him, just before Jonathan faints and gets taken to hospital.

Chloe Sullivan and Lana Lang decide to go to the scene of the car crash, where Chloe takes photos, and Lana finds the dead plant, which suddenly comes alive again just long enough to infect Lana. Lana goes on a hormone rampage, looking sexy in dark leather clothes, breaks up with Whitney Fordman and comes on to Clark in one of the steamiest scenes we may see in a while. She strips down to her sexy red underwear by the pool, impresses Clark with a back flip and kisses him passionately. She pushes Clark into the pool and leaves him wondering what happened as Principal Kwan finds him there, alone. Lana also comes onto Lex at the Talon, before driving off in his Porsche. When Clark catches up with her, she is half way up a windmill, at which point she faints and goes to the hospital.

Chloe discovers that the night she took photos, Dr. Hamilton was at the scene. When she visits him, she notices "the Nicodemus Diary", a book Lex had bought to Dr. Hamilton to question him about the history of the flower. She also notices all the flowers in the lab and a piece of meteor rock. She informs Clark that Lex is behind this, since he is funding Dr. Hamilton's research and that he is the one who checked the book out. When Clark confronts Lex, he denies it.

Finally, the last victim is Pete Ross, who comes onto Chloe, steals her car keys and storms into the Lex mansion accusing Lex of all this and showing his true hatred for the man. This was just at the time that Dr. Hamilton had found an old book that contained a Native American cure for the flower. Clark saves the day, as usual, and all the victims are saved in time, with no memory of their strange behavior.